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Synthesis and applications of RNAs with position-selective labelling and...

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Engineered CRISPR-Cas9 nucleases with altered PAM specificities

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High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target...

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Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling

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CRISPR–Cas encoding of a digital movie into the genomes of a population of...

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RNA targeting with CRISPR–Cas13

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Gigadalton-scale shape-programmable DNA assemblies

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Evolution of a designed protein assembly encapsulating its own RNA genome

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Acoustic reporter genes for noninvasive imaging of microorganisms in...

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De novo design of a fluorescence-activating β-barrel

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Transcriptional recording by CRISPR spacer acquisition from RNA

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Controlling orthogonal ribosome subunit interactions enables evolution of new...

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Transcriptome-wide off-target RNA editing induced by CRISPR-guided DNA base...

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An ultra-stable gold-coordinated protein cage displaying reversible assembly

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De novo design of bioactive protein switches

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Modular and tunable biological feedback control using a de novo protein switch

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Population imaging of neural activity in awake behaving mice

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An engineered PET depolymerase to break down and recycle plastic bottles

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Multispecific drugs herald a new era of biopharmaceutical innovation

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Computational design of transmembrane pores

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